- VEGF
Vascular Endothelial Growth Factor mediates angiogenesis, and has proven to be a high-interest target in oncology and other hyperproliferative diseases, such as Age-related Macular degeneration (AMD), our first indication we plan to target. - IL8
Interleukin-8 (IL8) is produced by most cells of the body, especially macrophages and endothelial cells.
It enhances inflammation, by enabling immune cells to migrate into tissue, and is a powerful inducer of chemotaxis for neutrophils. It is an interesting target in regard to Psoriasis. - IL4
There is evidence that overproduction of Interleukin-4 (IL4) as being a potentially important contributor to the inappropriate immune response leading to allergy and asthma.
